Dillon scored on runs of four, 48 and 78 yards as Washington (8-2) jumped to a 19-0 lead in the first 8 1/2 minutes of the game. He added the touchdown reception to extend the lead to 25-0 with 2:25 to play in the opening quarter.
Dillon, who has rushed for 1,440 yards this season, holds the school record for touchdowns in a season with 20 and the single-season record for all-purpose yards with 2,030, eclipsing the mark of 1,851 established in 1993 by Napoleon Kaufman.
"When you are told on the sidelines to be cautious of the clock because you are going to break the all-time NCAA record for yardage by a single running back in a quarter, it is very easy to be impressed with how that running back is doing," said Huskies coach Jim Lambright. "That was a tremendous thing to hear and right away I started to look at how quick will our defense get off the field, how fast can we get Corey back on the field. It is a tremendous compliment to Corey and our offense."
The 222 yards in the first quarter bettered the mark of 214 set by Andre Herrera of Southern Illinois, who accomplished the feat against Northern Illinois on October 23rd, 1976.
"He's an amazing back," said teammate Bob Sapp about Dillon. "He brings it with him all the time. The only thing more amazing is his last amazing play, so you just never know what is going to happen with Dillon is in. It's excellent to block for someone like that, I love it."
Terry Holliman ran for 148 yards and a touchdown for the Huskies, who are 7-0 against San Jose State. Maurice Shaw added 100 yards rushing on 14 carries for Washington, which amassed a school-record 734 total yards, including a school-record 559 on the ground.
San Jose State (2-9) fell to 0-4 against Pac-10 Conference opponents this season. The Spartans have lost to California, Stanford, Washington State and the Huskies by a combined score of 156-53.
"They're a very good football team," understated San Jose State coach John Rolston about Washington. "That's all you can say. A very, very good football team. They are well-coached, we knew they had some good football players, they played very well. They have all the ingredients and a good pass attack."
Linebacker Jacob Malae had 22 tackles for the Spartans.